Jonathan Henninger, Ph.D.

RNA-encoded enhancers and repressors in transcriptional control

Abstract

This research focuses on an overlooked gene expression regulation mechanism that Dr. Henninger discovered in which RNAs regulate their own production. Traditionally, it is believed that regulation of RNA production occurs primarily through the activity of specialized proteins that promote or repress gene expression. Dr. Henninger seeks to explore this newly discovered regulation mechanism by understanding how widely this mechanism is used in cells as well as the molecular basis for its function. If successful in whole or in part, it is the opinion of the Scientific Advisory Board that this project will cause a paradigm shift in how biologists think about gene expression regulation. 

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