Priya Sivaramakrishnan, Ph.D.

The choice between RNA and DNA - the cost of conflicts on DNA for embryonic cell fate programming.

Abstract

This research seeks to understand how conflicts between DNA replication machinery and transcription machinery are prevented to avoid genome breakage and how conflicts are resolved with DNA repair machinery when genome breakage occurs. The proposal utilizes two sequencing approaches on the model organism C. elegans to map interactions between these different kinds of cellular machinery. The Scientific Advisory Board believes this research has a strong likelihood of producing significant insights into developmental disorders if successful.

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