The goal of the Integrated Research-Education Grants (IREG) program is to provide support for research that focuses on direct engagement of undergraduate students alongside innovative scientists engaged in basic, fundamental research in Pennsylvania. Applications must include authentic, hands-on research experiences with the expectation of leading to new discoveries and peer-reviewed publications. Proposals are required to address basic (fundamental, pure) questions addressing core principles in biology, physics and chemistry or at the disciplinary boundaries between these fields. The research must be curiosity-driven addressing fundamental processes, but in the context of its potential application for the betterment of humankind. Applied or clinical studies will not be supported. Competitive applications are expected to be rich in innovative ideas and approaches with the potential both for generating transformative intellectual advances and for training the next generation of research scientists.